He is openly gay. A least easily known of his sib, a majority of his film operate has been limited to sale-budget or even independent films. These use at times involved his critically acclaimed debut performance when transsexual Georgette in Last Exit to Brooklyn. He too appeared within I Think I Do, Children of the Corn V and Killer Drag Queens on Dope, among 40 more independent pictures.

Arquette has infrequently popped withwithin offbeat supporting roles in mainstream films, including Pulp Fiction, Threesome, Bride of Chucky and a memorable appearance as a Boy George impersonator in The Wedding Singer. Arquette is easily known within California for his drag persona "Eva Destruction", and he has as well performed inside on line-budget pornographic films.

Around September 2005 VH1 announced his casting in an approaching year of the reality indicate The Surreal Life.

Around 2004 Arquette expressed an interest in fully making the transition from either male to female per utilize of endocrine treatments &, at long last, the sex reassignment surgery.